charts

People

Atul J. Butte, M.D., Ph.D.
Assistant Professor of Medicine (Biomedical Informatics) and Pediatrics
Contact Information
abuttestanford.edu
650-723-3465 (office)
650-723-7070 (fax)
See Med Profile
Research Interests

Translational bioinformatics has been defined as the development of analytic, storage, and interpretive methods to optimize the transformation of increasingly voluminous genomic and biological data into diagnostics and therapeutics for the clinician.

The long-term research goal of the Butte Lab is to develop translational bioinformatics methods to reason over many available genome-scale measurement and experimental modalities, and apply these methods to study complex disorders in genomic medicine, especially obesity and type 2 diabetes mellitus.

The Butte Lab has three main directions in exploring integrative biology. First, we have developed bioinformatics methods to integrate genomic, genetic, phenotypic, clinical, and gene-knockout data from multiple sources and phenotypes and reason over these data. An example of this was our recent work in adipogenesis published in Nature Cell Biology (2005) and in obesity in Bioinformatics (2007, in press). Second, we have developed tools to automatically index and find genomic and proteomic data sets based on the phenotypic and contextual details of each experiment. We used these tools to create a comprehensive phenome-genome network published in Nature Biotechnology (2006). Third, we are building a novel gene-expression-based classification scheme for diseases across the entire field of medicine. Initial work on this will appear in Nature Methods (2007, in press).

Atul Butte, M.D., Ph.D. is an Assistant Professor in Medicine (Medical Informatics) and Pediatrics at the Stanford University School of Medicine and the Lucile Packard Children’s Hospital, and a board-certified pediatric endocrinologist. Dr. Butte received his undergraduate degree in Computer Science from Brown University in 1991, and worked in several stints as a software engineer at Apple Computer (on the System 7 team) and Microsoft Corporation (on the Excel team). He graduated from the Brown University School of Medicine in 1995, during which he worked as a research fellow at NIDDK through the Howard Hughes/NIH Research Scholars Program. He completed his residency in Pediatrics and Fellowship in Pediatric Endocrinology in 2001, both at Children’s Hospital, Boston. Dr. Butte received a Ph.D. in Health Sciences and Technology from the Medical Engineering / Medical Physics Program in the Division of Health Sciences and Technology, at Harvard Medical School and Massachusetts Institute of Technology.

Dr. Butte’s laboratory focuses on solving problems relevant to genomic medicine by developing new methodologies in translational bioinformatics. Dr. Butte has authored more than 30 publications in bioinformatics, medical informatics, and molecular diabetes, and has delivered more than 70 presentations world-wide on bioinformatics, including 13 at the National Institutes of Health or NIH-sponsored meetings. Along with Isaac Kohane and Alvin Kho, Dr. Butte has co-authored one of the first books on microarray analysis titled Microarrays for an Integrative Genomics published by MIT Press. Dr. Butte’s recent awards include the 2007 Genome Technology “Tomorrow’s Principal Investigator” Award, the 2006 Howard Hughes Medical Institute Early Career Award, the 2006 PhRMA Foundation Research Starter Grant in Informatics, the 2002 and 2003 American Association for Clinical Chemistry Outstanding Speaker Award, and the 2001 Lawson Wilkins Pediatric Endocrine Society Clinical Scholar Award. Dr. Butte’s research is supported by grants from the Howard Hughes Medical Institute, the National Library of Medicine, the National Institute for General Medical Science, the National Human Genome Research Institute, the National Cancer Institute, the Pharmaceutical Research and Manufacturers of America Foundation, and the California Institute for Regenerative Medicine.

Publications Only the 5 most recent displayed   View All

SMI-2008-1306
Ontology-driven Indexing of Public Datasets for Translational Bioinformatics
N. H. Shah, A. P. Chiang, A. J. Butte, R. Chen, M. A. Musen
American Medical Informatics Association Symposium on Translational Bioinformatics, San Francisco, CA, March 10-12, 2008. Published 2008
SMI-2008-1303
The Ultimate Model Organism
A. J. Butte
Science, 320, 5874, 325-327. Published 2008
SMI-2008-1293
Novel Integration of Hopsital Electronic Medical Records and Gene Expression Measurements to Identify Genetic Markers of Maturation
D. P. Chen, S. C. Weber, P. S. Constantinou, T. A. Ferris, H. J. Lowe, A. J. Butte
Pacific Symposium on Biocomputing, Big Island, Hawaii, 13, 243-254. Published 2008
SMI-2008-1292
Enabling Integrative Genomic Analysis of High-Impact Human Diseases through Text Mining
J. Dudley, A. J. Butte
Pacific Symposium on Biocomputing, Big Island, Hawaii, 13, 580-591. Published 2008
SMI-2007-1297
Methodologies for Extracting Functional Pharmacogenomic Experiments from International Repository
Y. Lin, A. P. Chiang, P. Yao, R. Chen, A. J. Butte, R. S. Lin
AMIA Annual Symposium, Chicago, IL, 463-467. Published 2007

Projects

AILUN
View Project
Diabetes and Obesity Integrative Genomics
View Project
Genomic Nosology for Medicine (GNOMED)
View Project
Genotext
View Project
Relevance Networks
View Project
Stem Cell Informatics
View Project

 

print Printer-friendly version
 
Stanford School of Medicine