GLIF is a representation language that was developed to facilitate sharing of clinical guidelines. The latest draft GLIF version, GLIF 3, aims at enabling guideline specifications to be not only readable, but also computable on virtual machines and able to be integrated into institutional applications. The development of a domain ontology is part of the effort to achieve such goals. The domain ontology is critical to unambiguous representation of guidelines and to sharing of guidelines in diverse clinical information systems environments.