Publications

Publication details

Integrating Genotype and Phenotype Information: An: Conference Proceeding
Reference:: T. E. Klein, J. T. Chang, M. K. Cho, K. L. Easton, R. Fergerson, M. Hewett, Z. Lin, S. Liu, D. E. Oliver, D. L. Rubin, F. Shafa, J. M. Stuart, R. B. Altman. . Published in 2002.
Abstract:: Pharmacogenetics seeks to explain how people respond in different ways to the same drug treatment. A classic example of the importance of pharmacogenomics is the variation in individual responses to the anti-leukemia drug, 6-mercaptopurine. Most people metabolize the drug quickly. Some individuals, with a genetic variation for the enzyme thiopurine methyltransferase (TPMT),1 do not. Consequently, they need lower doses of 6-mercaptopurine for effective treatment as normal doses can be lethal. One of the many promises of the human genome project is an ability to pharmacologically treat individuals in a more personalized rather than statistical manner.
Full PDF version available here
Back to Search Results

Information last updated: Sat Jun 2 2007 Make Corrections to this Publication

	Go Stanford Biomedical Infomatics Only All of Stanford School of Medicine